Interactions of different drug resistance mutations in HIV Reverse Transcriptase in defining patterns of drug resistance
نویسندگان
چکیده
منابع مشابه
Reverse transcriptase inhibitors drug resistance mutations in drug-naive HIV type 1 positive Kenyans.
OBJECTIVE To evaluate the extent of HIV-1 drug resistance among drug naive Kenyan individuals. DESIGN Cross-sectional study. SETTING Kenya Medical Research Institute HIV laboratory Nairobi, Kenya. SUBJECTS A total of seventy eight HIV-1 positive drug naive subjects randomised from five Kenyan provincial hospitals between April and June 2004. RESULTS A major non-nucleoside reverse transc...
متن کاملMutations in HIV-1 Reverse Transcriptase and Protease Associated with Drug Resistance
The knowledge of HIV-1 drug resistance continues to increase at an exponential rate. This is particularly true for resistance to HIV-1 protease inhibitors, for which the first resistant variants were described less than two years ago (Otto et al., PNAS 90:7453–7457, 1993). Now resistance to virtually all classes of protease inhibitors has been documented. To keep our readership informed of newl...
متن کاملHIV-1 protease and reverse transcriptase mutations for drug resistance surveillance.
OBJECTIVES Monitoring regional levels of transmitted HIV-1 resistance informs treatment guidelines and provides feedback on the success of HIV-1 prevention efforts. Surveillance programs for estimating the frequency of transmitted resistance are being developed in both industrialized and resource-poor countries. However, such programs will not produce comparable estimates unless a standardized ...
متن کاملHiv-1 Drug Resistance Mutations
Non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens have recently been used in HIV-1 infected children in resource-limited settings. Treatment failure with this regimen has become more common. A second regimen needs to be prepared for the Thai national program. Genotypic resistance testing was conducted among HIV-1 infected children who experienced virological failure with ant...
متن کاملDrug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors
Human immunodeficiency virus (HIV) causes approximately 2.5 million new infections every year, and nearly 1.6 million patients succumb to HIV each year. Several factors, including cross-species transmission and error-prone replication have resulted in extraordinary genetic diversity of HIV groups. One of these groups, known as group M (main) contains nine subtypes (A-D, F-H and J-K) and causes ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Retrovirology
سال: 2011
ISSN: 1742-4690
DOI: 10.1186/1742-4690-8-s2-o14